Table 2.

Areas Where Epigenetic Mechanisms have been Implicated in Human Nervous System Function.

Function or Disorder	Mechanism(s) Implicated
Learning and Memory	Histone Modifications, DNA Methylation piRNAs, miRNAs
Maternal Nurturing	Histone Modifications, DNA Methylation
Adult Neurogenesis	Histone Modifications, DNA Methylation
Stress Responses	Histone Modifications, DNA Methylation
Alzheimer’s Disease	Histone Modifications, DNA Methylation
Rett Syndrome	MeCP2 Methyl-Cytosine Binding
Fragile X Mental Retardation	DNA Methylation, miRNAs
Schizophrenia	DNA and Histone Methylation, miRNAs
Rubinstein-Taybi Syndrome	Histone Acetyl Transferase Deficiency
Angelman Syndrome	Genomic Imprinting (DNA Methylation)
Depression/Suicide	DNA Methylation
Bipolar Disorder	Histone Modifications, DNA Methylation miRNAs
Addiction and Reward Behavior	Histone Modifications, DNA Methylation miRNAs
PTSD	Histone Modifications, DNA Methylation
ATR-X Syndrome (α-Thalassemia MR)	SNF2 Chromatin Remodeling, H3.3
Cognitive Aging	Histone Modifications, DNA Methylation
Coffin-Lowry Syndrome	Histone Phosphorylation
Kleefstra Syndrome	Histone Methylation
Epilepsy	Histone Modifications, DNA Methylation miRNAs
Autism	Histone and DNA Methylation? miRNAs?