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. Author manuscript; available in PMC: 2014 Jan 2.
Published in final edited form as: Sci Signal. 2010 Nov 23;3(149):10.1126/scisignal.2001158. doi: 10.1126/scisignal.2001158

Fig. 7.

Fig. 7

Knockdown of HLA-I inhibits migration of endothelial cells. (A) Cells transfected with control siRNA or with siRNA against the integrin β4 subunit or the HLA-I heavy chain were plated on laminin-5 and stimulated with bFGF, and their migration across an artificial wound was measured. (B) Cells were transfected with control siRNA or with siRNA against the integrin β4 subunit, the HLA-I heavy chain, or β2-microglobulin and were pretreated with mitomycin C to inhibit cell proliferation before being assayed for their ability to migrate. The graphs show the mean percentage ± SEM of wound closure. *P < 0.05 by one-way ANOVA, Fisher's LSD (n = 9 experiments). Endothelial cells (EC1) were used in these experiments.