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. Author manuscript; available in PMC: 2014 Oct 15.
Published in final edited form as: Clin Cancer Res. 2013 Aug 22;19(20):10.1158/1078-0432.CCR-13-1323. doi: 10.1158/1078-0432.CCR-13-1323

Table 3.

FLT3 inhibitor IC50 values in Ba/F3 cells expressing FLT3 mutations.

Mutation IC50 (nM)a
Sorafenib Sunitinib Quizartinib Midostaurin
GFP + IL3 3900 2400 13,000 330
D835H 81 8.7 1.9 1.2
D835Y 210 13 11 1.5
ITD 1.1 1.8 0.15 4.5
ITD D835H 460 24 21 24
ITD D835Y 3300 57 150 33
ITD F691L 1300 32 210 19
a

Concentration inhibiting 50% of growth in a cell viability assay.