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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Prostate. 2013 Jul 3;73(14):10.1002/pros.22706. doi: 10.1002/pros.22706

Figure 1. TMEFF2 interaction with one-carbon metabolism.

Figure 1

The enzymes and metabolites discussed in this study are indicated in this schematic. TMEFF2 is shown interacting with SARDH. Changes in the expression of TMEFF2 affect the activity and/or expression of some of the enzymes of this pathway, and ultimately its balance, possibly affecting the methylation potential of the cell (see text). Negative regulation of GNMT by CH3-THF and of CH3-THF formation by SAM is indicated by dotted lines. SAH: S-adenosyl-homocysteine; Hy: homocysteine. Other abbreviations are as described throughout the manuscript.