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. Author manuscript; available in PMC: 2014 Jan 2.
Published in final edited form as: Nat Rev Drug Discov. 2010 Apr;9(4):10.1038/nrd3012. doi: 10.1038/nrd3012

Figure 1. A diverse array of disease-causing agents and glycan antigens are targeted by existing and developmental carbohydrate vaccines.

Figure 1

Bacteria: capsular polysaccharide repeats associated with particular species (and serotypes). Fungi: β-glucan (Candida, Cryptococcus and Aspergillus), β-mannan (Candida), common GXM motifs for serotypes A-D (Cryptococcus). Parasites: synthetic GPI motif (Plasmodium falciparum), common tyvelose-containing Ag (Trichinella), LDN(F) (Schistosoma), common LPG (Leishmania). Viruses: high mannose, GlcNAc2Man9 (HIV). Tumours: common glycan antigens associated with glycolipids (Globo H, Fucosyl GM1, LeY) and glycoproteins (TF, LeY, Tn, sTn and PSA) found on various malignant tissues, see Table 3.

* Mannose residues may be 6O-acetylated.