Table 2.
Comparisons of BRIDGE with CIPHER and ENDEAVOUR
| |
Artificial linkage interval |
Random control |
||||||
|---|---|---|---|---|---|---|---|---|
| TOP | AUC | FE | MRR | TOP | AUC | FE | MRR | |
| CIPHER1 |
47.41% |
86.08% |
51.66 |
16.94% |
42.07% |
82.23% |
42.07 |
18.05% |
| BRIDGE1 |
62.47% |
90.86% |
68.09 |
8.90% |
57.42% |
90.78% |
57.42 |
8.34% |
| ENDEAVOUR2 |
45.80% |
91.89% |
49.92 |
7.79% |
44.10% |
92.03% |
44.10 |
11.27% |
| BRIDGE2 | 66.15% | 94.17% | 72.10 | 6.73% | 63.50% | 93.85% | 63.50 | 6.95% |
1CIPHER and BRIDGE are evaluated using the 1,428 associations between 1,126 diseases and 938 genes. 2ENDEAVOUR and BRIDGE are evaluated using the 470 associations between 168 diseases and 375 genes.