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. 2013 Dec 18;11:96. doi: 10.1186/1478-811X-11-96

Figure 4.

Figure 4

Regulation of IR activation through PTP1B and Grb14. In support of our current findings, Figure 4 presents aggregate data based on the results from our previous studies of the IR kinase and PTP1B activities in wild-type, PTP1B KO, and Grb14 KO mice [8,10,19]. The IR immunoprecipitates from dark- and light-adapted wild-type, PTP1B-/-, and Grb14-/- mice were subjected to IR kinase activity employing poly Glu:Tyr peptide as a substrate (A). PTP1B activity was measured in retinas harvested from the dark- and light-adapted wild-type and Grb14-/- mice (B). Data are mean ± SD, n = 5, *p < 0.05. The IR kinase activity and PTP1B activity in dark-adapted retinas was set at 100%.