Table 1.
Top potential compounds for inhibition of platelet aggregation according to degree centrality of drug-target network
| Rank | Compound | Degree | CAS NO. | Chemical name |
|---|---|---|---|---|
| 1 |
CVDHD016293 |
6 |
62218-13-7 |
(+)-α-viniferin |
| 2 |
CVDHD027110 |
6 |
N/A |
hypericinate |
| 3 |
CVDHD007020 |
6 |
54352-30-6 |
tricrotonyltetramine |
| 4 |
CVDHD012997 |
6 |
N/A |
blumeanine |
| 5 |
CVDHD001236 |
5 |
N/A |
kadlongilactone B |
| 6 |
CVDHD012285 |
5 |
225662-66-8 |
hypericin radical cation |
| 7 |
CVDHD002703 |
5 |
50838-55-6 |
trisjuglone |
| 8 |
CVDHD032784 |
5 |
55954-61-5 |
pseudohypericine |
| 9 |
CVDHD029497 |
5 |
7034-04-0 |
tricrotonyltetramin |
| 10 |
CVDHD002390 |
4 |
N/A |
20(R)-21,24-Cyclo-3beta,25-dihydroxyldammar-23(24)-en-21-one |
| 11 |
CVDHD014854 |
4 |
N/A |
longipedlactone F |
| 12 |
CVDHD034764 |
4 |
N/A |
celastroline B alpha |
| 13 |
CVDHD010515 |
4 |
123522-98-5 |
isowithametelin |
| 14 |
CVDHD014739 |
4 |
N/A |
eremodimer B |
| 15 |
CVDHD025068 |
4 |
N/A |
bismorphine B |
| 16 |
CVDHD017384 |
4 |
1253379-22-4 |
dievodiamine |
| 17 |
CVDHD021374 |
4 |
N/A |
lycochinine B |
| 18 |
CVDHD025464 |
4 |
511-98-8 |
solasodanol |
| 19 |
CVDHD019403 |
4 |
129748-10-3 |
incarvillateine |
| 20 |
CVDHD019431 |
4 |
548-04-9 |
hypericin |
| 21 |
CVDHD029988 |
4 |
129225-31-6 |
aminopropylcanavalmine |
| 22 |
CVDHD009071 |
4 |
77646-14-1 |
3β,17α-Cinchophylline |
| 23 |
CVDHD015834 |
4 |
N/A |
bismorphine A |
| 24 | CVDHD011497 | 4 | N/A | dihydro-18,19 3β,17β cinchophylline |