Table 1.
Neuroimaging studies of attention and working memory processes in multiple sclerosis.
| Author, year | Healthy controls |
Patients |
Disease duration (y) | Type of disease | Cognitive paradigm | No of foci |
Stereotactic space | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Age (years) | N (f/m) | Age (years) | N (f/m) | Controls | Patients | |||||
| Amann et al., 2011 | 33.9 | 15 (5/10) | 37.6 | 15 (9/6) | 5.9 | RRMS | n-Back | 39 | 39 | TAL |
| Bonzano et al., 2009 | 18 | 32.5 | 23 (11/12) | 6.9 | RRMS | PVSAT | 16 | 11 | TAL | |
| Cader et al., 2006 | 39.0 | 16 (10/6) | 39.0 | 21 (15/6) | 6.0 | RRMS/RPMS | n-Back | 8 | 8 | MNI |
| Forn et al., 2007 | 10 (5/5) | 17 (12/5) | RRMS | n-Back | 10 | 10 | TAL | |||
| Forn et al., 2006 | 31.1 | 10 (5/5) | 32.7 | 15 (11/4) | RRMS | PASAT | 8 | 14 | TAL | |
| Li et al., 2004 | 40.6 | 5 | 47.8 | 8 | Auditory working memory task | 6 | 2 | TAL | ||
| Mainero et al., 2004 | 22 (11/11) | 30.5 | 22 (14/8) | 9.0 | RRMS | PASAT/recall task | 62 | 67 | TAL | |
| Penner et al., 2003 | 7 | 45.8 | 14 (13/1) | 11.4 | RRMS/SPMS | n-Back | 9 | 22 | TAL | |
| Sumowski et al., 2010 | − | − | 43.8 | 18 (15/3) | 9.5 | RRMS/SPMS | n-Back | − | 28 | TAL |
| Total | 103 | 153 | 158 | 201 | ||||||
RRMS, relapsing-remitting multiple sclerosis; RPMS, relapsing-progressive multiple sclerosis; SPMS, secondary progressive multiple sclerosis; PASAT, paced auditory serial attention task; PVSAT, paced visual serial attention task.