Fig. 2.

Dietary nitrate supplementation elevates plasma nitrite levels but does affect platelet reactivity in healthy female volunteers. Ex vivo platelet (PRP) aggregation assessed by light transmission aggregometry in response to (A, B) ADP (0.1–0.3 µmol/L), (C, D) collagen (0.1–30 µg/ml), and (E, F) epinephrine (0.001–100 µmol/L), and (G) plasma nitrate and (H) nitrite levels before and 3 h post placebo or dietary nitrate (beetroot juice, ∼3.1 mmol nitrate) consumption in females (n=12). Data are expressed as mean±SEM. Significance shown as ^⁎⁎⁎P<0.001 for Bonferroni post hoc tests following one-way ANOVA. (ADP, adenosine diphosphate; PRP, platelet-rich plasma).