Table 1.
ED50 values of AESP and met-AESP-induced hypotension.
| Model of rats | ED50 values for the induced hypotension | |||||
|---|---|---|---|---|---|---|
| AESP | Met-AESP | |||||
| MAP | SBP | DBP | MAP | SBP | DBP | |
| WKY | 25.28 ± 2.33 | 21.80 ± 2.34 | 26.67 ± 2.34 | 54.58 ± 2.41 | 63.83 ± 2.37 | 72.14 ± 2.43 |
| SHR | 32.28 ± 2.53 | 26.32 ± 2.52 | 32.97 ± 2.58 | 33.05 ± 2.34 | 32.08 ± 2.36 | 32.25 ± 2.34 |
ED50 value: mean of dose ± SD that causes 50% maximal reduction of MAP, SBP, and DBP, calculated by GraphPad PRISM version 5.01 software by using nonlinear regression equation, MAP: mean arterial blood pressure, SBP: systolic blood pressure, DBP: diastolic blood pressure, AESP: aqueous extract of S. polyanthum leaves, met-AESP: residual methanolic extract of S. polyanthum leaves, WKY: Wistar-Kyoto rats, SHR: spontaneously hypertensive rats.