Table 2.
Top canonical pathways generated by Ingenuity Pathway Analysis (IPA)
| Ingenuity canonical pathways | p -value | Ratio | Molecules | |
|---|---|---|---|---|
|
A |
TREM1 signaling |
2.71 × 10-11 |
1.69 × 10-1 |
IL8, CXCL3, ICAM1, CD40, GRB2, IL10, TLR8, CASP1, IL1B, FCGR2B, NFKB1, TNF |
| |
Hepatic fibrosis/hepatic stellate cell activation |
8.32 × 10-11 |
1.10 × 10-1 |
CXCL3, IL8, IL4R, CCR5, ICAM1, CD40, MYL6, IL10, IL6R, IL1B, IFNGR1, CCL5, NFKB1, TNF, CCR7, IL4 |
| |
IL-10 signaling |
3.82 × 10-9 |
1.41 × 10-1 |
TRAF6, SOCS3, FOS, IL4R, CCR5, MAPK14, IL10, IL1B, FCGR2B, NFKB1, TNF |
| |
IL-12 signaling and production in macrophages |
6.87 × 10-9 |
8.97 × 10-2 |
IL10, MAF, IFNGR1, NFKB1, IRF1, TRAF6, FOS, MAPK14, CD40, ZNF668, NOS2, TNF, PRKD3, IL4 |
| |
IL-17A signaling in gastric cells |
3.33 × 10-8 |
2.80 × 10-1 |
IL8, FOS, MAPK14, CCL20, CCL5, NFKB1, TNF |
|
B |
Role of cytokines in mediating communication between immune cells |
8.88 × 10-7 |
7.27 × 10-2 |
IL8, IFNB1, IL13, IL4 |
| |
Communication between innate and adaptive immune cells |
6.73 × 10-6 |
3.67 × 10-2 |
IL8, IFNB1, CCR7, IL4 |
| |
Airway inflammation in asthma |
1.81 × 10-5 |
3.33 × 10-1 |
IL13, IL4 |
| |
Remodeling of epithelial adherens junctions |
1.08 × 10-4 |
4.41 × 10-2 |
ACTR3, MAPRE1, CLIP1 |
| Prolactin signaling | 1.5 × 10-4 | 3.75 × 10-2 | SOCS3, FOS, IRF1 |
A) The list of differentially regulated on microarray (n = 418) and Ensembl reannotated genes was used as an input for IPA; B) Subset of these genes (n = 28; List eQG from [18]) was used as an input.