Table 5.

Top upstream regulators identified by Ingenuity Pathway Analysis (IPA)

	Top upstream regulators	p -value
A	CD40 ligand (CD154)	2.25 × 10-24
	TNF receptor superfamily member 5 (CD40)	1.05 × 10-22
	Interleukin 10 (IL-10)	1.01 × 10-21
	5′-inosinic acid (poly rI:rC)	1.73 × 10-20
	Lipopolysaccharide (LPS)	6.21 × 10-20
B	Peptidoglycan	1.79 × 10-13
	Suppressor of cytokine signaling 1 (SOCS1)	7.66 × 10-13
	Tyrphostin AG490 (AG490)	1.71 × 10-12
	Interleukin 10 (IL-10)	3.52 × 10-12
	Toll-like receptor 2 (TLR2)	3.55 × 10-12

A) The list of differentially regulated on microarray (n = 418) and Ensembl reannotated genes was used as an input for IPA; B) Subset of these genes (n = 28; List eQG from [18]) was used as an input.