Table 1.

Clinical, genetic and radiological features of CADASIL patients with ICH

Author	Sex/age	Vascular risk factors	Symptoms	Antithrombotics or statins	Location of ICH	Gene mutation		Number of CMBs
						Exon	Amino acid
Werbrouck [5]	M/45	HT, HC	Migraine, CI, ICH	NA	Basal ganglia	4	R182C	6
Oh [6]	M/39	Smoking, HT, alcohol	CI, ICH	Anticoagulant and statins	Temporal lobe	11	R544C	NA
Sano [7]	M/46	Smoking	CI,Dementia, ICH	Antiplatelet	Putamen	6	A332C	NA
Maclean [8]	M/56	Smoking, alcohol	CI, ICH	Antiplatelet	Frontal lobe	4	R133C	1
Choi [9,18]	F/68	HT	TIA, Dementia, ICH	Antiplatelet (3)	Cerebellum	11	R578C	27
	M/69	HT,DM	Dementia, ICH		Thalamus Parietal lobe	11	R544C	85
	M/61	HT, alcohol	ICH, Headache		Basal ganglia	11	R544C	14
	M/48	HT	ICH, TIA		Basal ganglia	11	R544C	5
	F/86	HT, HC	Headache, ICH Gait difficulty		Thalamus	NA	NA	32
Lee [10]	M/43	HT	Gait difficulty, CI, ICH	Antiplatelet(5)	Thalamus	4	R133C	NA
	F/56	HT	ICH		Thalamus	11	R544C	NA
	M/57	HT	CI, ICH		Temporal lobe	11	R544C	NA
	M/56	HT	CI, ICH		Putamen, Parietal lobe	11	R544C	NA
	M/35	HT	Gait difficulty, ICH		Putamen	11	R544C	NA
Ragoschke-Schumm [11]	F/47	HT	CI, ICH	NA	Cerebellum	NA	NA	25
Pradotto [12]	M/65	NA	Dementia, ICH	Anticoagulant	Frontal lobe	13	A680G	3
Kotorii [13]	F/72	NA	Gait difficulty, CI Dementia, ICH	NA	Temporal lobe	18	G975C	NA
Rinnoci [14]	M/54	HT	ICH	NA	Basal ganglia	22	A1231C	25
	F/67	HT, Smoking	ICH	NA	Basal ganglia	22	A1231C	3
	M/77	HT, Smoking	ICH, Dementia	NA	Basal ganglia	14	A728C	2
	M/39	HC, DM	SAH	NA	Interpeduncular cistern	24	C1298P	25
This	M/46	Smoking	CI,ICH	Statins	Basal ganglia	3	A90C	18

ICH,intracerebral hemorrhage; CMBs,cerebral microbleeds; HT,hypertension; DM,diabetes mellitus; HC,hypercholesterolemia; CI, cerebral infarctionr; TIA, transient ischemic attack; SAH, subarachnoid hemorrhage; NA, not available.