TABLE 2.
Antigens and peptide pools evaluated and number of donors who responded to each peptide pool by IFN-γ-ELISPOT assay
| Region of difference and designation | Size (amino acids) | Putative functionc | Peptide pool (no. of constituent peptides) | Region of molecule represented by peptide pools (amino acid position) | No. of TB patients responding (n = 49) | No. of unexposed, BCG- vaccinated donors responding (n = 38) |
|---|---|---|---|---|---|---|
| RD1 | ||||||
| Rv 3873 | 368 | M. tuberculosis PPE family member | 1 (6) | 89-128 | 8 | 0 |
| 2 (6) | 129-158 | 25 | 2 | |||
| 3 (6) | 159-188 | 18 | 1 | |||
| Rv 3878 | 280 | Unknown alanine-rich protein | 1 (7) | 1-45 | 16 | 1 |
| 2 (7) | 36-80 | 14 | 1 | |||
| Rv 3879c | 729 | Unknown alanine- and proline- | 1 (6) | 1-40 | 12a | 1 |
| rich protein | 2 (6) | 31-70 | 18a | 0 | ||
| 3 (5) | 61-95 | 9b | 0 | |||
| RD2, Rv 1989c | 186 | Unknown | 1 (6) | 1-40 | 10b | 0 |
| 2 (6) | 31-70 | 7b | 0 | |||
| 3 (6) | 61-100 | 8b | 0 |