Table 2.
Entry | Chalcone | Ar1 | Ar2 | Prod. | Yielda (%) | er b (+/−) |
---|---|---|---|---|---|---|
1 | 2 | Ph | Ph | 3c | 82 | 13:87 |
2 | 7 | 4-ClC6H4 | Ph | 8 | 98 | 12:88 |
3 | 9 | Ph | 4-ClC6H4 | 10 | 91 | 11:89 |
4 | 11 | Ph | 4-FC6H4 | 12 | 72 | 13:87 |
5 | 13 | 3-NO2C6H4 | Ph | 14 | 59 | 9:91 |
6 | 15 | 4-NO2C6H4 | Ph | 16 | 58 | 10:90 |
7 | 17 | Ph | 4-MeC6H4 | 18 | 72 | 16:84 |
8 | 19 | 4-OH-C6H4 | Ph | 20 | Nrc | Nd |
9 | 21 | Ph | 4-OH-C6H4 | 22 | Nrc | Nd |
10 | 23 | 4-MeO-C6H4 | Ph | 24 | Nrc | Nd |
11 | 25 | Ph | 4-MeO-C6H4 | 26 | Nrc | Nd |
Isolated yield.
Determined by HPLC using a chiral stationary phase.
Only dimerization of 1c.