Table 1.
Strain | C57BL/6 | MRL | MRL/lpr | ||||||
---|---|---|---|---|---|---|---|---|---|
Treatment | 9 weeks | PBS | HyperPRL | 9 weeks | PBS | HyperPRL | 9 weeks | PBS | HyperPRL |
PRL (ng/mL) | 4.2 ± 1.3 | 3.8 ± 1.1 | 10.7 ± 1.2* | 12.5 ± 1.9 | 11.2 ± 1.8 | 26.27 ± 2.9* | 12.7 ± 2.2 | 20.0 ± 2.7* | 34.5 ± 4.3* |
Proteinuria (mg/mL) | 0 | 0 | 0 | 10.1 ± 7.2 | 12.8 ± 5.6 | 121.6 ± 37.4* | 13.5 ± 8.5 | 48.0 ± 18.6* | 166.6 ± 23.5* |
Ab anti-dsDNA (μg/mL) | 0 | 0 | 0 | 0 | 5.9 ± 1.9* | 22.9 ± 5.1* | 2.5 ± 0.05 | 11.6 ± 1.2* | 22.5 ± 5.1* |
HyperPRL: hyperprolactinemia.
*ANOVA, P < 0.05.