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. Author manuscript; available in PMC: 2014 Jan 2.
Published in final edited form as: Nat Rev Mol Cell Biol. 2013 Jun 19;14(7):10.1038/nrm3609. doi: 10.1038/nrm3609

Figure 5. A new model for the activation of cofilin in invasive protrusions.

Figure 5

Tyr phosphorylation of cortactin by Arg kinase, which is activated downstream of epidermal growth factor receptor (EGFR), regulates the interaction between the Na+–H+ exchanger 1 (NHE1) and cortactin. The recruitment of phosphorylated cortactin to NHE1 may be mediated by ERM (ezrin–radixin–moesin) proteins. NHE1 increases the intracellular pH, which induces the release of cortactin-bound cofilin.