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. Author manuscript; available in PMC: 2014 Jan 2.
Published in final edited form as: Inflamm Bowel Dis. 2011 Sep 26;18(5):10.1002/ibd.21867. doi: 10.1002/ibd.21867

Figure 5.

Figure 5

Imiquimod increases expression of AMPs in dendritic cells and reduces extracellular survival of Salmonella. CD11c+ cells isolated from GM-CSF-treated mice were stimulated with Imiquimod (10 μg/ml) for 24 hours. (A) Stimulated CD11c+ cells exhibited significant increases in expression of AMPs, including Defensins a1, Defensins related cryptdins (4, 6 & 20), Cathelicidin and s1008 a. (B) Media supernatant collected from the cultures of Imiquimod-treated CD11c+ cells were inoculated with Salmonella typhimurium for 1 hour. Serially diluted media were plated on agar plates for colony counts. Significantly reduced number of surviving Salmonella was observed with Imiquimod treatment. Results are representative of three individual experiments (* P < .05).