Table I.
List of Imiquimod-induced IFN and AMPs genes in mice colons
| Gene Name | Accesion no. | Gene Description | 6 h | 18 h |
|---|---|---|---|---|
| Oasl2 | NM_011854 | 2’-5’ oligoadenylate synthetase-like 2 | 13.6 | 12.3 |
| Oasl1 | NM_145209 | 2’-5’ oligoadenylate synthetase-like 1 | 6.3 | 4.2 |
| Oas3 | NM_145226 | 2’-5’ oligoadenylate synthetase 3 | 2.4 | 3.4 |
| Oas2 | NM_145227 | 2’-5’ oligoadenylate synthetase 2 | 11.7 | 12.8 |
| Oas1g | NM_011852 | 2’-5’ oligoadenylate synthetase 1G | 2.6 | 2.1 |
| Oas1f | NM_145153 | 2’-5’ oligoadenylate synthetase 1F | 3.5 | 3.8 |
| Oas1b | NM_011853 | 2’-5’ oligoadenylate synthetase 1B | 2.2 | 2.4 |
| Oas1a | NM_145211 | 2’-5’ oligoadenylate synthetase 1A | 4.3 | 4.7 |
| Isg20 | NM_020583 | interferon-stimulated protein | 2.1 | 1.7 |
| Isg20 | NM_020583 | interferon-stimulated protein | 1.8 | 1.8 |
| Irf7 | NM_016850 | interferon regulatory factor 7 | 2.7 | 5.0 |
| Irf1 | NM_008390 | interferon regulatory factor 1 | 1.6 | 1.6 |
| Ifrg15 | NM_022329 | interferon alpha responsive gene | 2.1 | 1.9 |
| Ifrg15 | NM_022329 | interferon alpha responsive gene | 2.0 | 1.7 |
| Ifitm7 | NM_028968 | interferon induced transmembrane protein 7 | 3.2 | 2.8 |
| Ifitm3 | NM_025378 | interferon induced transmembrane protein 3 | 3.1 | 2.6 |
| Ifit3 | NM_010501 | interferon-induced protein with tetratricopeptide repeats 3 | 5.2 | 3.5 |
| Ifit2 | NM_008332 | interferon-induced protein with tetratricopeptide repeats 2 | 6.9 | 3.2 |
| Ifit1 | NM_008331 | interferon-induced protein with tetratricopeptide repeats 1 | 37.0 | 12.4 |
| Ifih1 | NM_027835 | interferon induced with helicase C domain 1 | 2.7 | 2.0 |
| Ifi44 | NM_133871 | interferon-induced protein 44 | 15.8 | 16.4 |
| Ifi205 | NM_172648 | interferon activated gene 205 | 3.2 | 1.6 |
| Ifi204 | NM_008329 | interferon activated gene 204 | 3.8 | 2.2 |
| Hamp2 | NM_183257 | hepcidin antimicrobial peptide 2 | 1.5 | 1.3 |
| Hamp1 | NM_032541 | hepcidin antimicrobial peptide 1 | 2.5 | 1.2 |
| Defcr6 | NM_007852 | defensin related cryptdin 6 | 0.6 | 3.1 |
| Defcr4 | NM_010039 | defensin related cryptdin 4 | 0.5 | 3.9 |
| Defcr3 | NM_007850 | defensin related cryptdin 3 | 0.6 | 3.7 |
| Defcr23 | NM_001012307 | defensin-related cryptdin 23 | 0.6 | 3.7 |
| Defcr22 | NM_207658 | defensin-related cryptdin 22 | 0.7 | 2.3 |
| Defcr20 | NM_183268 | defensin related cryptdin 20 | 0.5 | 3.4 |
| Defcr-rs7 | NM_007848 | defensin related cryptdin related sequence 7 | 0.5 | 4.4 |
| Defcr-rs2 | NM_007847 | defensin related cryptdin related sequence 2 | 0.6 | 7.2 |
| Defcr-rs12 | NM_007846 | defensin related cryptdin related sequence 12 | 0.5 | 4.3 |
| Defcr-rs10 | NM_007845 | defensin related cryptdin related sequence 10 | 0.5 | 6.3 |
| Defcr-rs1 | NM_007844 | defensin related sequence cryptdin peptide (paneth cells) | 0.8 | 2.2 |
| Defb1 | NM_007843 | defensin beta 1 | 1.9 | 0.8 |
| Defa1 | NM_010031 | defensin alpha 1 | 0.6 | 3.4 |
Following microarray analysis, Imiquimod treatments increased a total of 116 gene expression in colon. A list of important IFN and AMPs genes are included in the table. The fold differences are based on 2 array experiments