Table 1.
Gene ontology analysis of differentially expressed genes
| Gene ontology term | GO category | Efron-Tibshirani’s GSA test p-value |
|---|---|---|
|
Collagen/extracellular matrix association |
|
|
| Collagen binding |
GO:0005518 |
< 0.005 |
| Collagen metabolic process |
GO:0032963 |
0.05 |
| Collagen catabolic process |
GO:0030574 |
0.035 |
| Integrin complex |
GO:0008305 |
< 0.005 |
| Substrate-bound cell migration |
GO:0006929 |
< 0.005 |
| Negative regulation of cytoskeleton organization |
GO:0051494 |
0.025 |
|
Nitric oxide/monooxygenase activity |
|
|
| Regulation of monooxygenase activity |
GO:0032768 |
< 0.005 |
| Regulation of oxidoreductase activity |
GO:0051341 |
< 0.005 |
| Regulation of nitric-oxide synthase activity |
GO:0050999 |
0.005 |
| Nitric oxide biosynthetic process |
GO:0006809 |
0.015 |
| Positive regulation of monooxygenase activity |
GO:0032770 |
0.005 |
| Nitric oxide metabolic process |
GO:0046209 |
0.01 |
| Regulation of nitric oxide biosynthetic process |
GO:0045428 |
0.005 |
| Regulation of calcidiol 1-monooxygenase activity |
GO:0060558 |
0.005 |
|
Immune associated functions |
|
|
| B cell receptor signaling pathway |
GO:0050853 |
0.015 |
| Regulation of leukocyte mediated immunity |
GO:0002703 |
0.02 |
| Response to interferon-gamma |
GO:0034341 |
0.005 |
| Positive regulation of B cell activation |
GO:0050871 |
0.04 |
| Humoral immune response mediated by circulating immunoglobulin |
GO:0002455 |
0.02 |
| Myeloid cell activation during immune response |
GO:0002275 |
0.01 |
| Regulation of lymphocyte mediated immunity |
GO:0002706 |
0.035 |
|
Muscle/myocyte/myofibroblast biology |
|
|
| Dystroglycan binding |
GO:0002162 |
0.015 |
| Myosin complex |
GO:0016459 |
0.01 |
| Muscle filament sliding |
GO:0030049 |
0.02 |
| Actin-myosin filament sliding |
GO:0033275 |
0.02 |
| Myosin II complex |
GO:0016460 |
0.025 |
| Actomyosin structure organization |
GO:0031032 |
0.04 |
| Regulation of myoblast differentiation |
GO:0045661 |
0.03 |
| Muscle myosin complex |
GO:0005859 |
0.02 |
| Myoblast differentiation |
GO:0045445 |
0.02 |
| Regulation of myotube differentiation |
GO:0010830 |
0.015 |
| Myotube differentiation | GO:0014902 | 0.005 |
Gene ontology (GO) analysis was undertaken using BRB Array Tools. Significantly altered genesets were identified using Efron-Tibshirani’s Gene Set Analysis (GSA) test which tests which genesets contain more differentially expressed genes than would be expected by chance. The threshold of determining significant gene sets was 0.005.