Figure 3.

Target molecule kinetics during therapeutic plasma exchange. (A) Theoretical relationship between an increasing plasma volume exchanged relative to the patient’s plasma volume during the TPE procedure, and the percentage decrease in the concentration of the target molecule under idealized conditions. (B) Similar figure showing removal of target molecule from the beginning (closed circles) to the end of each of three TPE procedures (open circles), now taking into account factors such as biosynthesis, catabolism, and compartmental equilibration. Adapted from Kaplan (1) and Samtleben et al. (2). TPE, therapeutic plasma exchange.