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Structure and activity of the arimetamycins. (a) Chemical structures of arimetamycins A – C (1 – 3). Only relative configuration is shown for the aglycone moiety. (b) Cytotoxicity assay against the four human carcinoma cell lines. Previously reported IC50 values for steffimycin against the MDAMB231 and HT-29 (WiDr) are 4,870 and 6,790 nM, respectively.[21]
