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. Author manuscript; available in PMC: 2014 Oct 11.
Published in final edited form as: Angew Chem Int Ed Engl. 2013 Sep 3;52(42):10.1002/anie.201305109. doi: 10.1002/anie.201305109

Figure 4.

Figure 4

Heterologous production and proposed biosynthesis of the arimetamycins based on gene fuction prediction by sequence homology and domain analysis. (a) The arm (arimetamycin) gene cluster spanning roughly 40 kb and containing 36 predicted ORFs (GenBank KF040454). (b) HPLC analysis of fermentation broth extracts showing arimetamycins A – C production by S. albus/AZ129/pIJRham. (c) Proposed biosynthetic scheme for the arimetamycins based on the gene prediction with the aid of Pfam domain analysis. See supplementary figure 3 for an expanded biosynthesis scheme and supplementary table 4 for a complete arm cluster gene table.