TABLE 3.
Effect of orbA and fptA mutations on persistence of B. cenocepacia Pc715j in the rat lung chronic-infection model
| Expt | Strain | Inoculum (log CFU) | Log CFU/ml of lung homogenatea
|
|
|---|---|---|---|---|
| Day 7 p.i. | Day 14 p.i. | |||
| 1 | Pc715j | 4.7 | 5.5 ± 0.82 | 3.8 ± 1.6 |
| Pc715jorbA::tp | 4.6 | 2.0 ± 2.5b | 0.4 ± 0.7b | |
| 2 | Pc715j | 5.8 | 5.0 ± 0.3 | 3.5 ± 1.5* |
| Pc715jfptA::tp | 6.0 | 5.2 ± 0.5 | 4.9 ± 0.7* | |
a
Values are means ± standard deviations for four animals per group or, if marked with an asterisk, five animals per group at 7 and 14 days postinfection (p.i.).
b
Significantly different from results for Pc715j (P < 0.05) by analysis of variance, Bonferroni multiple-comparisons test.