Table 1.
Prevalence of intestinal schistosomiasis across the SIMI young child cohort
| Environment | Diagnostic | Baseline % (95% CI) | 3-month % (95% CI) | 6-month % (95% CI) | 12-month % (95% CI) | 18-month % (95% CI) |
|---|---|---|---|---|---|---|
| Lake Alberta | Kato–Katz | 44.5% (40.3–48.7) |
ND | 30.7% (26.0–35.7) |
37.6% (32.6–42.7) |
Cohort closed |
| (n = 572) | Urine CCA | 59.3% (54.9–63.5) |
52.1% (47.4–56.7) |
63.4% (58.4–68.2) |
51.0% (45.9–56.2) |
– |
| SEA-ELISA | 72.0% (68.1–75.7) |
ND | 83.2% (79.2–86.7) |
87.2% (83.5–90.4) |
– | |
| Lake Victoriaa | Kato–Katz | 13.2% (10.8–16.0) |
ND | 7.5% (5.2–10.4) |
14.5% (11.3–18.3) |
11.1% (8.2–14.5) |
| (n = 639) | Urine CCA | 43.2% (39.2–47.2) |
39.7% (35.4–44.0) |
40.2% (35.7–44.8) |
40.7% (36.0–45.5) |
34.2% (29.7–39.0) |
| SEA-ELISA | 40.8% (37.0–44.8) |
ND | 43.6% (39.2–48.2) |
26.4% (22.3–30.8) |
47.1% (42.3–51.9) |
a
In comparison to baseline, the average cohort recovery at each follow-up time point was 70%, that is, an initial loss of approximately 30% at 6-month follow-up thereupon with minimal subsequent drop-outs. During an 18-month study period, as estimated by different diagnostic methods, intestinal schistosomiasis is shown to be a chronic public health problem despite access to PZQ.