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. 2004 May;72(5):2635–2647. doi: 10.1128/IAI.72.5.2635-2647.2004

FIG. 7.

FIG. 7.

Isotype responses to SmCT-SOD-derived peptides. Reactivity of IgG1 (A), IgG2a (B), IgG2b (C), and IgG3 (D) antibodies from pooled sera of mice immunized with 5 mg of SmCT-SOD-GST-encapsulated microspheres/mouse (Microspheres-1); equivalent amount of SmCT-SOD-GST microspheres capable of releasing 50 μg/100 μl/mouse (Microspheres-2); 50 μg of CT-SOD-GST mixed in alum/100 μl/mouse (Alum); 100 μg of SmCT-SOD DNA/100 μl/mouse (DNA) against SmCT-SOD antigens (2 μg/ml) and SmCT-SOD derived-peptides (2 μg/ml). The sera of the Microspheres-1 group were diluted starting from 1:2,500. The line represents the cutoff value (mean OD + 3 SD) of preimmune sera.