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. 2013 Dec 10;5(1):23. doi: 10.1186/1868-7083-5-23

Figure 1.

Figure 1

Comparison of methylation indices in control samples and patients with Beckwith-Wiedemann syndrome (BWS) at PLAGL1- (n = 176 BWS patients) (A), MEST- (n = 167 BWS patients) (B), and IGF2R-associated DMRs (n = 167 BWS patients) (C). For all three loci the distribution of MIs did not correspond to a normal distribution and there was an increased frequency of outliers with low methylation index in the BWS patient samples (D’Agostino-Pearson test for normal distribution rejected (P <0.0001) at PLAGL1, MEST and IGF2R).