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Representative DXA images of the rabbit distal femur after 10 days' treatment with ALN or ODN. Note increased density of secondary spongiosa with ALN or ODN as compared to vehicle. (a) vehicle (DFBMD = 263 mg/cm2), (b) ALN (DFBMD = 361 mg/cm2), and (c) ODN 3 mg/kg (DFBMD = 388 mg/cm2). ALN = alendronate (100 μg/kg/day), DFBMD = distal femur bone mineral density, DXA = dual energy x-ray absorptiometry, ODN = odanacatib.
