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. 2013 Dec 9;20(1):92. doi: 10.1186/1423-0127-20-92

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Copyright © 2013 Skipper et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Model of cut-and-paste transposition. Transposase proteins (green spheres) recognize the terminal inverted repeats (IRs, orange boxes) and form a circular pre-excision synaptic complex from which the transposon is excised. Formation of the synaptic complex, allowing close association of the two transposon ends, involves the formation of transposase tetramers [74]. Subsequently, the transposition complex recognises a target site and the transposase proteins mediate integration of the transposon. The figure shows the proposed mechanisms for Tc1/mariner-type (e.g. Sleeping Beauty) DNA transposition. Yellow boxes marked with IR represent the terminal inverted repeats.