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Models of replicative transposition. (A) After replication, the transposon is excised and integrated into a yet unreplicated genomic site thus duplicating the newly inserted transposon. (B) The double-stranded break created by transposition at newly replicated DNA is repaired using the sister chromatid as a template for homology-directed DNA repair, leading to reconstitution of the excised transposon. IR, terminal inverted repeat.
