Table 2.
Sequential changes in variables of lung mechanics and hemodynamics
| Variables | Group | Baseline | Injury | 1 Hr | 2 Hr | 3 Hr | 4 Hr | 5 Hr | 6 Hr |
|---|---|---|---|---|---|---|---|---|---|
| PIP, cmH2O |
OS |
13.0 ± 3.0 |
19.3 ± 3.0
a
|
22.6 ± 2.1
ad
|
23.0 ± 2.6 |
23.0 ± 2.1 |
23.8 ± 2.1 |
24.6 ± 2.6
b
|
24.9 ± 2.9
b
|
| |
CS |
13.2 ± 1.7 |
19.4 ± 2.6
a
|
21.2 ± 1.6
d
|
21.3 ± 2.3 |
21.3 ± 2.3 |
21.5 ± 1.9
c
|
21.5 ± 2.2
c
|
21.8 ± 2.2
c
|
| |
Control |
13.2 ± 2.0 |
20.5 ± 2.1
a
|
20.8 ± 1.0
d
|
21.3 ± 1.0 |
21.0 ± 1.3 |
20.3 ± 1.4
c
|
19.8 ± 1.2
c
|
19.2 ± 1.5
c
|
| |
HC |
13.7 ± 1.5 |
17.7 ± 0.6 |
17.3 ± 0.6 |
19.3 ± 1.2 |
19.6 ± 2.3 |
19.3 ± 2.5
c
|
19.0 ± 2.0
c
|
18.3 ± 1.2
c
|
| Arterial pH |
OS |
7.43 ± 0.03 |
7.05 ± 0.14
a
|
7.15 ± 0.13
a
|
7.14 ± 0.13 |
7.11 ± 0.12 |
7.09 ± 0.15 |
7.09 ± 0.17 |
7.11 ± 0.14 |
| |
CS |
7.40 ± 0.05 |
7.11 ± 0.15
a
|
7.16 ± 0.11 |
7.15 ± 0.10 |
7.16 ± 0.14 |
7.12 ± 0.14 |
7.14 ± 0.08 |
7.17 ± 0.09 |
| |
Control |
7.48 ± 0.08 |
7.20 ± 0.08
a
|
7.22 ± 0.06 |
7.23 ± 0.06 |
7.26 ± 0.03 |
7.26 ± 0.05 |
7.24 ± 0.05 |
7.22 ± 0.06 |
| |
HC |
7.41 ± 0.06 |
7.22 ± 0.04 |
7.24 ± 0.02 |
7.23 ± 0.03 |
7.22 ± 0.03 |
7.24 ± 0.05 |
7.24 ± 0.05 |
7.20 ± 0.04 |
| MAP, mmHg |
OS |
131 ± 17 |
118 ± 20 |
98 ± 14
a
|
102 ± 16 |
101 ± 14b |
100 ± 20 |
97 ± 11 |
95 ± 16 |
| |
CS |
119 ± 13 |
121 ± 18 |
101 ± 14
a
|
102 ± 12 |
94 ± 15 |
94 ± 16 |
94 ± 16 |
91 ± 15 |
| |
Control |
116 ± 7 |
119 ± 11 |
93 ± 10
a
|
95 ± 11 |
96 ± 9 |
102 ± 13 |
106 ± 13 |
105 ± 9 |
| |
HC |
118 ± 2 |
111 ± 6 |
105 ± 13 |
112 ± 26 |
100 ± 15 |
96 ± 6 |
102 ± 16 |
105 ± 15 |
| HR, beats/min |
OS |
241 ± 64 |
209 ± 31 |
217 ± 43 |
215 ± 24 |
200 ± 19 |
211 ± 36 |
211 ± 37 |
207 ± 31 |
| |
CS |
214 ± 49 |
195 ± 29 |
221 ± 49 |
218 ± 32 |
227 ± 43 |
224 ±49 |
208 ± 34 |
212 ± 27 |
| |
Control |
272 ± 49 |
242 ± 53 |
244 ± 30 |
253 ± 37 |
252 ± 37
c
|
243 ± 39 |
232 ± 39 |
235 ± 20 |
| HC | 299 ± 38 | 207 ± 140 | 231 ± 11 | 228 ± 24 | 225 ± 11 | 253 ± 15 | 247 ± 45 | 235 ± 44 |
OS, open endotracheal suctioning; CS, closed endotracheal suctioning; HC, Healthy control; PIP, peak inspiratory pressure; MAP, mean arterial pressure; HR, heart rate. a p < 0.05 compared with previous value within the same group; b p < 0.05 compared with 1 hour after injury within the same group; c p < 0.05 vs. OS group; d p < 0.05 vs. HC group. Values are mean ± SD.