Table III.
Pearson's Correlation Table
| Gli2. Epithelium | Gli2 Stroma | Gli1 Epithelium | Gli1 Stroma | Smoothened Epithelium | Smoothened Stroma | Shh Epithelium | Shh Stroma | |
|---|---|---|---|---|---|---|---|---|
| Gli2. Epithelium | 1 | 0.789 | 0.349 | 0.485 | 0.516 | 0.359 | 0.349 | 0.545 |
| Gli2 Stroma | 0.789 | 1 | 0.305 | 0.52 | 0.443 | 0.601 | 0.305 | 0.731 |
| Gli1 Epithelium | 0.485 | 0.52 | 1 | 0.393 | 0.479 | 0.418 | 0.306 | 0.505 |
| Gli1 Stroma | 0.290 | 0.363 | 0.362 | 1 | 0.286 | 0.381 | 0.362 | 0.455 |
| Smoothened Epithelium | 0.516 | 0.443 | 0.496 | 0.418 | 1 | 0.449 | 0.496 | 0.359 |
| Smoothened Stroma | 0.359 | 0.601 | 0.172 | 0.286 | 0.449 | 1 | 0.172 | 0.552 |
| Shh Epithelium | 0.349 | 0.305 | 1 | 0.306 | 0.496 | 0.172 | 1 | 0.333 |
| Shh Stroma | 0.545 | 0.731 | 0.505 | 0.455 | 0.359 | 0.552 | 0.333 | 1 |
Active Hh signaling was parallel in the tumor epithelium and adjacent stroma, as primarily indicated by the increased correlation (0.78) in gli2 expression. The paracrine activity of the pathway is supported by correlation of the Shh ligand stromal expression and pathway component expression in the tumor epithelium.