Table 3.
Previously published case-series in the literature of brain metastasis from HCC
| Author (year) | Patient number | Age (median) | Median interval between diagnosis of HCC and brain metastasis (months) | Median survival (weeks) | Treatment for brain metastasis | Survival time (weeks) | Positive prognostic factor |
|---|---|---|---|---|---|---|---|
| Chang et al. (2004) |
45 |
NA |
10.5 |
4 |
Resection and/or radiotherapy |
>16 |
Single lesion |
| Supportive care |
<4 |
||||||
| Choi et al. (2009) |
62 |
54 |
18.2 |
6.8 |
Resection and WBRT |
33.6 |
Single lesion, Child-Pugh’s classification A Any treatment modalities for brain metastasis |
| Resection or WBRT or GKS |
10 |
||||||
| Steroids alone |
2 |
||||||
| Hsieh et al. (2009) |
42 |
55.8 |
15.4 |
4.8 |
NA |
NA |
ICH did not influence |
| Han et al. (2010) |
20 |
55 |
18.5 |
8 |
Resection and WBRT |
8 |
Younger age, Extracranial metastasis |
| WBRT and/or GKS |
16 |
||||||
| Jiang et al. (2012) |
41 |
48.5 |
15 |
12 |
Resection or WBRT or GKS |
18 |
No extracranial metastasis, Low RPA class, Any treatment modalities for brain metastasis |
| Steroids alone |
10.8 |
||||||
| Present Study (2013) | 33 | 62 | 18.3 | 10.4 | Resection/Resection+WBRT |
25.3 |
No intratumoral bleeding Child-Pugh’s classification A, Resection for brain metastasis |
| WBRT/GKS/WBRT+GKS |
10.4 |
||||||
| Steroids alone | 1.0 |