TABLE 2.
Detection of pneumococci in lung homogenates of mice immunized with BVH-3M, BVH-11M, or the chimeric CH-3C-11B recombinant protein
| Immunogen | CFU/100 μl of lung homogenatesa
|
|
|---|---|---|
| Day 2 postinfection | Day 3 postinfection | |
| BVH-3M | 191 (10, 15, 150, 150, 630) | 24 (< 5, < 5, < 5, < 5, 100) |
| BVH-11M | 148 (10, 25, 70, 135, 500) | 4 (< 5, < 5, < 5, < 5, < 5) |
| CH-3C-11B | 56 (<5, <5, <5, <5, 260) | 159 (< 5, < 5, 20, 75, 690) |
| Quil A alone | 4.3 × 105 ([2.8, 3.2, 4.6, 7.0, 8.0] × 105) | 2.4 × 106 ([1.9, 2.2, 3.2] × 106)b |
a
Arithmetic mean of CFU values. CFU values for individual mice are indicated in parentheses. Values of 4 and 6.6 × 106 CFU/100 μl were assigned to samples without any colonies and to dead animals, respectively, to calculate arithmetic means.
b
In two mice from the Quil A group, death occurred between day 2 and day 3 postinfection.