TABLE 1.
IL-12 reduces pathology in the lungs of infected micea
| TB-infected mice and treatment | % of granulomatous regions on day:
|
||
|---|---|---|---|
| 28 | 42 | 56 | |
| WT plus IL-12 | 40.3 ± 8.5 | 34.6 ± 3.9** | 66.4 ± 0.8** |
| WT plus saline | 49.6 ± 7.8 | 68.3 ± 3.4 | 78.1 ± 2.8 |
| CD4−/− plus IL-12 | 36.9 ± 6.9 | 53.6 ± 8.9 | 80.5 ± 1.4 |
| CD4−/− plus saline | 34.2 ± 13.0 | 65.8 ± 5.6 | 78.5 ± 4.4 |
a
MetaMorph analysis was performed on digital microscopy of hematoxylin-and-eosin-stained tissue sections (×2 magnification). Percentages were calculated by the equation [granulomatous regions (measured in pixels)/total lung area (in pixels)] × 100. Each value represents the mean of three or four mice ± the standard error. The data are representative of three experiments with CD4−/− mice and four experiments with WT mice. **, P < 0.01 when comparing treatments within WT or CD4−/− groups.