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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Trends Immunol. 2013 Jul 16;34(10):10.1016/j.it.2013.06.004. doi: 10.1016/j.it.2013.06.004

Figure 3. Immune response in the thymus.

Figure 3

Schematic representation of microbial dissemination and recruitment of an immune response to the thymus. Under normal conditions, mature T cells and DC circulate from peripheral lymphoid organs to the thymus (left panel). Following infection, pathogens disseminate from the periphery to the thymus, either extracellularly or within re-circulating cells. The infected thymus produces chemokines, such as CXCL9 and CXCL10, which recruit CXCR3-expressing antigen-specific T cells from the peripheral tissues back to the thymus to fight infection (right panel). LN – lymph node.