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. 2014 Jan 2;10(1):e1004004. doi: 10.1371/journal.pgen.1004004

Figure 6. Revised model of the Cdk1 activation loop.

Figure 6

The regulation of Gwl dephosphorylation by PP2A/B55 and Ensa/ARPP19 dephosphorylation by Fcp1 are incorporated into the previous network shown on Fig. 1A. Since Fcp1 is inhibited in Cdk1 dependent manner, Ensa is regulated by a coherent feed-forward loop as well: Cdk1 both activates the phosphorylation (via Gwl) and inhibits the dephosphorylation (via Fcp1) of Ensa.