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. 2014 Jan 2;10(1):e1004055. doi: 10.1371/journal.pgen.1004055

Table 1. Mutation in Sfswap results in fewer hair cells.

Cochlear Region Row WT Count Tg/Tg Count P value
Apex IHC 24.2+/−0.49 37.2+/−3.10 0.003
Row1 OHC 27.4+/−0.51 27.6+/−1.78 NS
Row2 OHC 28.4+/−0.51 27.6+/−1.91 NS
Row3 OHC 28.8+/−0.37 16.4+/−2.54 0.0013
Middle IHC 24.8+/−0.37 22.2+/−0.58 0.006
Row1 OHC 26.0+/−0.95 27.2+/−0.86 NS
Row2 OHC 26.2+/−0.66 26.0+/−0.55 NS
Row3 OHC 26.6+/−0.75 3.0+/−1.48 5.9E-7
Base IHC 22.4+/−0.68 21.6+/−0.81 NS
Row1 OHC 24.5+/−0.65 25+/−0.58 NS
Row2 OHC 25.2+/−0.80 25.8+/−0.80 NS
Row3 OHC 25.6+/−1.17 13.0+/−2.53 0.0088
Whole Cochlea IHC 644+/−10.5 402+/−5.03 1.6E-4
OHC 2066+/−29 1021+/−26.2 1.2E-4

The number of hair cells in each row per 200 µm was collected at the apex, mid and base in P0 cochleas. In SfswapTg/Tg mutants, the third row of outer hair cells is reduced in all areas. Loss is greatest in the middle cochlea. The number of inner hair cells is significantly increased at the apex. The total number of hair cells was counted in WT and Tg/Tg cochleas at P2 and mutants show a significant decrease in both inner and outer hair cells.