Figure 3. Temporal profile of the mouse liver proteome across two consecutive cycles.

(A) Hierarchical clustering of daily rhythmic proteins in mouse liver according to the phase of maximal expression. Values for each protein (rows) at all the circadian times analyzed (columns) are colored based on the abundance ratios, high (light blue) and low (yellow) values (Z-scored normalized ratios) are indicated in the color scale bar at the bottom. Top gray bars indicate the circadian day (light gray) and night (dark gray) of the two consecutive sampled cycles. (B) Plots display the abundance profile of proteins (grey lines) from the day (upper) and night (lower) branches of the dendrogram across the two circadian cycles. Red line represented the calculated median profile in each cluster. Protein categories enriched (FDR<0.05) in each protein cluster are indicated on the right side using a color to indicate the annotation database they belong to.