Figure 7. Survival of C57BL/6 mice vaccinated against Pks domains and challenged with M. ulcerans 1615.

Ten mice/group were challenged 6 weeks after the protein boost with 10⁵ AFB of M. ulcerans 1615 and subsequently monitored for 112 days for footpad swelling after M. ulcerans 1615 infection. Animals were euthanized when footpad swelling exceeded 4 mm. Figure shows the percentage of surviving mice during the 112 day follow-up. A: Survival curves of unvaccinated (ctrl) mice or mice vaccinated with ACP1, ACP2, ACP3, ATac1, ATac2 or M. bovis BCG. B: Survival curves of unvaccinated (ctrl) mice or mice vaccinated with ATp, ER, KR A, KS, Ag85A or M. bovis BCG.