Figure 4. Mouse survival as a function of dosing period before lethal influenza A virus challenge.

Mice received PBS and xylitol 2 (33 mg/kg/day) in combination with the water soluble fraction (0.25 mg/kg/day) orally for 0, 1, 3 or 5 days prior to influenza A virus challenge. Details of the administration protocols are presented in Table 2. Panels A, B, C and D are survivals following administration for 0, 1, 3 and 5 days prior to virus challenge. After challenge with 2X LD₅₀ of influenza A virus, each regimen was continued for 3 days and survival was monitored for 14 days post challenge. PBS, n = 5; xylitol 2+ water soluble fraction, n = 5; oseltamivir, n = 3.