Table 1.

Partial list of proteins overexpressed in serum samples of chikungunya patients

	Protein	Gene symbol	RefSeq accession	Description	Fold change (chikungunya/control)
1	SH3 and PX domain-containing protein 2B	DLST	NP_001017995.1	It is an adapter protein and is involved in cell adhesion and migration of numerous cell types. It interacts with Fas-ligand, which is a cytotoxic effector molecule of T and NK cells.	6
2	Optineurin	OPTN	NP_001008214.1	It is a coiled-coil containing protein that interacts with viral protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction.	5
3	Spermine synthase	SMS	NP_004586.2	Its deficiency is shown to impair neurodevelopment and cognitive ability.	5
4	Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial	SUCLA2	NP_003841.1	It is a mitochondrial matrix enzyme that hydrolyzes ATP to convert succinate to succinyl-CoA.	4
5	Apolipoprotein A-IV	APOA4	NP_000473.2	Apolipoproteinis an activator of lecithin-cholesterol acyltransferase.	4
6	Apolipoprotein C-I	APOC1	NP_001636.1	It is known to be activated upon differentiation of monocytes to macrophages.	4
7	Probable ATP-dependent RNA helicase DDX23	DDX23	NP_004809.2	It is a component of the U5 snRNP complex and has been reported to be upregulated upon induction of viral replication.	3
8	Haptoglobin isoform 1 preproprotein	HP	NP_005134.1	Haptoglobin binds to free plasma hemoglobin, and enables hemoglobin degradation. It also prevents loss of iron through kidneys and protects damage of kidneys from hemoglobin.	3
9	Glutamyl aminopeptidase	ENPEP	NP_001968.3	It is an aminopeptidase and is involved in the regulation of blood pressure.	2
10	Clusterin	CLU	NP_001822.3	It is a secreted chaperone. It is known to be involved in events such as cell death and neurodegenerative disorders.	2