Figure 3.

Modular structure of AgMNPV-2D network unveiled with GLay clustering method. The five different communities are ordered by their size and are populated with some particular distinctions. The comparative amount of gene function in each community is represented by colored rectangles. Community I is densely populated with subsets of nodes associated with structural functions; community II has subsets of nodes more related to DNA replication and auxiliary functions; community III is homogeneously populated with nodes from different functional categories; community IV includes diverse genes without assigned functions; and community V is the smallest, where helicase (ORF 92) is located. Nodes represent ORFs of AgMNPV-2D and have colors according to the functional classification based on prior knowledge about baculovirus genes. Nodes also have different size representing the importance (betweenness centrality) of the ORF in the complete GRN (see Figure 2).