Table 2.
Non-Food and Drug Administration approved/investigational agents and their mechanism
| Drug name | Mechanism of action |
| Induction | |
| Efalizumab1 | Humanized antibody, CD11a/LFA-1 |
| Alefacept1 | Costimulation inhibitor, CD2 LFA3 |
| Maintenance | |
| Voclosporin, ISA247 | Calcineurin inhibitor |
| Sotrastaurin, AEB0711 | Protein kinase C inhibitor |
| Tofacitinib, CP-6905501 | JAK 3 inhibitor |
| ASKP1240 | Anti-CD40 monoclonal antibody |
| Treatment of Antibody Medicated Rejection | |
| Bortezomib | Proteasome inhibitor |
| Eculizumab | Monoclonal antibody, C5 complement protein |
1
No longer being investigated for transplantation.