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. 2013 Nov 26;289(1):264–274. doi: 10.1074/jbc.M113.495499

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FIGURE 3. — Field potential recordings of the corticostriatal transmission and evoked DA overflow in the presence of cocaine in DAT-CI mice. A, cocaine (Coca) (30 μm) did not change the amplitude of the field potential (97 ± 2% of control (Ctrl), n = 4, p = 0.618 F (0.28), one-way ANOVA), whereas it reduced the evoked DA overflow to 51 ± 2% of control (n = 4, p = 0.0002 F (60.36), one-way ANOVA). B, the reducing effects of cocaine (10 μm) (n = 49) when coapplied with the other DAT inhibitor nomifensine (30 μm, n = 6) (by 50 ± 2%, n = 6, p = 0.179 F (2.12), one-way ANOVA), the SERT blocker fluoxetine (10 μm, n = 8) (by 49 ± 2%, n = 8, p = 0.094 F (3.24), one-way ANOVA), the NET blocker reboxetine (10 μm) (by 56 ± 2% (n = 5, p = 0.944 F (0.005), one-way ANOVA), and the adrenergic antagonists phentolamine (3 μm) (by 40 ± 7%, n = 6, p = 0.560 F (0.344), one-way ANOVA) and pindolol (1 μm) (by 37 ± 11%, n = 4, p = 0.409 F (0.691)). Note that neither of these treatments modified the effects of cocaine. ns, not significant.