FIGURE 10.

Latrophilins and their ligands are differentially regulated during neurodegeneration in CSPα KO mice. Quantitative RT-PCR measurements of selected proteins in brains of adult CSPα KO mice and WT littermates. Results are represented for mRNA samples as follows: A, were down-regulated; B, were unchanged, or C, were up-regulated in brain samples of CSPα KO mice compared with WT littermates. All mRNA levels were normalized to those of actin as an internal control and then to the mRNA levels of the respective proteins in WT littermates. Data shown are means ± S.E. (n = 4). Statistical significance was assessed by Student's t test comparing KO to WT conditions (*, p < 0.05; **, p < 0.01). α-Syn, α-synuclein; APP, amyloid precursor protein; Cdh2, N-cadherin; DAG, dystroglycan; LRRTM2, leucine-rich repeat transmembrane-2; MAG, myelin-associated glycoprotein; NL1, neuroligin-1; NL2, neuroligin-2; NRXN1, neurexin-1; SNAP25, synaptosomal associated protein-25; SynCAM, synaptic cell-adhesion molecule-1; Syb2, synaptobrevin-2; Syt1, synaptotagmin-1.