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KMUP-1 prevented serotonin-induced H9c2 cardiomyocyte hypertrophy. H9c2 cells were cultured in serum-free medium and treated with 10 μM serotonin, 10 μM serotonin+0.1-10 μM KMUP-1, 10 μM serotonin+1 μM verapamil, 10 μM serotonin+0.1 μM ketanserin or10 μM serotonin+0.1 μM SB206553 for 4 days. The cell surface areas (≥30 cells) were analyzed in each condition using ImageJ 1.47 software. Data are means ± SE, n=6. ** P<0.01 compared with control. ## P<0.01 compared with serotonin group.
