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. 2013 Dec 17;10(1):64–72. doi: 10.7150/ijbs.7894

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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Effects of KMUP-1 on serotonin-increased I_Ca,L via the PKC pathway in hypertrophic H9c2 cells. (A) Representative recordings of I_Ca,Levoked by test pulse to 0 mV from a holding potential of -80 mV in H9c2 cells. Cells were treated with 10 μM serotonin, 1 μM chelerythrine, 10 μM serotonin+1 μM chelerythrine, 10 μM serotonin+1 μM KMUP-1, 10 μM serotonin+1 μM PMA or 10 μM serotonin+1 μM PMA+1 μM KMUP-1 for 4 days. (B) Bar graph showing the relative I_Ca,L averaged from the recordings of trace (A). Data are means ± SE, n=8. ^**P<0.01, ^***P <0.001 compared with control.^###P<0.001 compared with the serotonin group. ^✝P <0.001 compared with the serotonin+PMA group.