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. 2013 Dec 22;10(1):90–102. doi: 10.7150/ijbs.7738

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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Fig 4 — Knockdown of TRPM8 inhibited cell migration and invasion. A: Knockdown of TRPM8 inhibited cell migration in MG-63 (a) and U2OS (b) cells (magnification x200). (c) The migration rate was expressed as a percentage with the value of Parental cells being 100% and the migration was significantly suppressed in siTRPM8 cells,^**P<0.01. B: Knockdown of TRPM8 inhibited cell invasion. (a) The invaded siTRPM8 cells were obviously less than the invaded Parental and siCON cells (magnification x200). (b) Values are presented as invaded cells/field, ^**P<0.01. C: (a) Knockdown of TRPM8 suppressed the expression of pFAK and MMP-2. (b) The western blot results were quantified and statistic analysis was performed, ^**P<0.01,^*P<0.05. All the data in this figure was analyzed by One-Way ANOVA.